Found inside â Page 95Role of body fat distribution and the metabolic complications of obesity. ... tissue as a generator of risk factors for cardiovascular disease and diabetes. FOIA This volume was authored by the participants in a 1998 AHA sponsored conference on the impact of obesity on cardiovascular disease. Found insideThe book would hopefully be useful for anyone interested in recapitulating endothelial (patho)physiology and expanding knowledge of molecular mechanisms involved in endothelial dysfunction, relevant also for further clinical investigations. echocardiography assessments. Found inside â Page 143Lindström J, Tuomilehto J: The diabetes risk score: a practical tool to predict type 2 diabetes ... and risk of type 2 diabetes or cardiovascular disease. Funding: Correction to: Obesity Phenotypes, Diabetes, and Cardiovascular Diseases. UM1 CA186107/CA/NCI NIH HHS/United States, R01 HL034594/HL/NHLBI NIH HHS/United States, R01 HL088521/HL/NHLBI NIH HHS/United States. Lancet Diabetes Endocrinol. Interpretation: Even when metabolic health is maintained during long periods of time, obesity remains a risk factor for cardiovascular disease. Cardiovascular and Metabolic Heterogeneity of Obesity: Clinical Challenges and Implications for Management. Circ Res, 126 (11) (2020), pp. However, risks are highest for metabolically unhealthy women across all BMI categories. This is especially the case given the so-called "obesity paradox" of apparently improved outcomes with a higher BMI. Diabetes and hypertension have evolved as two of the modern day epidemics affecting millions of people around the world. 1-Deoxynojirimycin (Duvoglustat) is a potent and orally active α-glucosidase inhibitor. Found inside â Page iThe book defines obesity and realistically assesses its prevalence. It further examines and evaluates the success of traditional cognitive behavioral treatment. This volume is a thorough reference for obesity and the metabolic syndrome. 2021 Jul 1;8:681581. doi: 10.3389/fcvm.2021.681581. Would you like email updates of new search results? Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association scientific statement on obesity and heart disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. 1-3 The global prevalence of DM in 2019 was estimated to be 9.3% (463 million people), with a . RESEARCH DESIGN AND METHODS We included patients from the Prospective Multicenter . Individualized medicine initiatives mainly focus on rare diseases or cancer. Obesity must be considered a real pathology. PMC OBJECTIVE It is controversial whether adults who are obese but "metabolically healthy" have cardiovascular disease (CVD) risk comparable with that of normal-weight adults. This book comprises chapters written by leading international experts on various aspects of obesity-related diabetes. As a practical reference guide, it is suitable for all professionals with an interest in this field. Comparison of widely used JAX Mice fortype 2 diabetes and obesity. On the basis of the above, we propose that we should refer to obesities rather than obesity. but for CVD the risk is as elevated in both obesity phenotypes. Are metabolically healthy overweight and obesity benign conditions? Clipboard, Search History, and several other advanced features are temporarily unavailable. Growing evidence also shows that obesity and metabolic diseases accelerate aging process. Visceral obesity is associated with CVD, heart failure (HF), diabetes, non-alcoholic fatty liver disease, and nephropathy, resulting in increased mortality [20,21]. Genetic association of anthropometric traits with type 2 diabetes in ethnically endogamous Sindhi families. 2021 Aug 27;8:721956. doi: 10.3389/fcvm.2021.721956. OBJECTIVE Obesity and metabolic syndrome are associated with major adverse cardiovascular events (MACE). Obesity phenotypes were significantly correlated with CIMTb. Furthermore, multiple animal and human clinical studies revealed striking association between either . Introduction. Current evidence remains inconsistent with regard to the association between different triglyceridemic-waist phenotypes and the risks for type 2 diabetes mellitus (T2DM). 2014 Jan-Feb;56(4):369-81. doi: 10.1016/j.pcad.2013.10.016. J Am Heart Assoc. Commodore-Mensah, Y. et al. Prog Cardiovasc Dis. Machine Learning to Identify Metabolic Subtypes of Obesity: A Multi-Center Study. Obesity is a global public health threat that is associated with additional metabolic abnormalities (i.e., insulin resistance, dyslipidemia) that increase the risk of common diseases such as diabetes and cardiovascular disease. Found inside â Page 294Routes to obesity: Phenotypes, food choices and activity. ... positively associated with obesity, diabetes, hypertension, and cardiovascular disease among ... Disclaimer, National Library of Medicine Obesity remains a leading cause of type 2 diabetes mellitus (DM), cardiovascular diseases (CVDs), and stroke and has substantially increased the public health burden [1,2,3,4].To evaluate obesity accurately, direct fat mass measurement should be performed with computed tomography, magnetic resonance imaging, whole body dual-energy X-ray absorptiometry (DXA), or positron emission . 62 Subsequent studies have confirmed the obesity paradox in both HF with reduced LVEF (HFrEF) and HFpEF. Careers. Type 2 diabetes, though poorly understood, is known to be a disease characterized by an inadequate beta-cell response to the progressive insulin resistance that typically accompanies advancing age . doi: 10.1371/journal.pmed.1003351. Gao M, Lv J, Yu C, Guo Y, Bian Z, Yang R, Du H, Yang L, Chen Y, Li Z, Zhang X, Chen J, Qi L, Chen Z, Huang T, Li L; China Kadoorie Biobank (CKB) Collaborative Group. eCollection 2021. INTRODUCTION. Nutrition provides early prediction and mechanistic assessment of Metabolism and Cardiovascular Diseases 2007, 17(4):319-326. eCollection 2020 Oct. Murphy N, Cross AJ, Abubakar M, Jenab M, Aleksandrova K, Boutron-Ruault MC, Dossus L, Racine A, Kühn T, Katzke VA, Tjønneland A, Petersen KE, Overvad K, Quirós JR, Jakszyn P, Molina-Montes E, Dorronsoro M, Huerta JM, Barricarte A, Khaw KT, Wareham N, Travis RC, Trichopoulou A, Lagiou P, Trichopoulos D, Masala G, Krogh V, Tumino R, Vineis P, Panico S, Bueno-de-Mesquita HB, Siersema PD, Peeters PH, Ohlsson B, Ericson U, Palmqvist R, Nyström H, Weiderpass E, Skeie G, Freisling H, Kong SY, Tsilidis K, Muller DC, Riboli E, Gunter MJ. Found inside â Page 1Filled with timely new content, this updated edition covers: New discoveries that have changed our understanding of the pathogenesis and interrelationship of metabolic syndrome, cardiovascular disease (CHD), and type 2 diabetes mellitus ... Diabetes . PLoS One. Ritchie SA, Connell JMC: The link between abdominal obesity, 33. Overweight or obesity, in fact, significantly increases the risk of contracting diseases, such as: arterial hypertension, dyslipidemia, type 2 diabetes mellitus, coronary heart disease, cerebral vasculopathy, gallbladder . Obesity is an independent risk factor for cardiovascular diseases. doi: 10.1371/journal.pone.0154273. This review addresses the interplay between obesity, type 2 diabetes mellitus, and cardiovascular diseases. eCollection 2021. 2017 Mar 8;6(3):e004199. Fielden MR, Brennan R, Gollub J: A gene expression biomarker metabolic syndrome and cardiovascular disease. Piché ME, Poirier P, Lemieux I, Després JP. Estimates of the age-adjusted prevalence of obesity and severe obesity increased significantly among adults, but not among children and adolescents, in the U.S. between 2001-2004 and 2013-2016. : A systematic review and meta-analysis. Introduction. doi: 10.1371/journal.pmed.1001988. Currently in the United States about 97 million adults are considered obese, accounting for about 33% of the American adult population (compared to 22.9% in 1988). Introduction. 1 In addition . Request PDF | Obesity Phenotypes, Diabetes, and Cardiovascular Diseases | This review addresses the interplay between obesity, type 2 diabetes mellitus, and cardiovascular diseases. Metabolically healthy obese and cardiovascular disease. Careers. Obesity is a notorious risk factor for cardiovascular disease (CVD) and its prevalence continues to rise rapidly, throughout the world [].Similarly, prevalence of obesity (BMI≥ 30 kg/m 2), which is reported to be 17.4%, has an ascending trend in Iranian population [].Variable distribution of metabolic risk factors across the spectrum of BMI has resulted in different obesity . Because of the difficulties of normalizing body fat content in patients with severe obesity, more aggressive treatments have been studied in this subgroup of individuals such as obesity surgery, also referred to as metabolic surgery. It is proposed that obesity, generally defined by an excess of body fat causing prejudice to health, can no longer . Found insideSeveral associations were observed between other obesity-related traits and ... abnormalities associated with type 2 diabetes and cardiovascular disease in ... Introduction. 2013 Dec 3;159(11):758-69. doi: 10.7326/0003-4819-159-11-201312030-00008. Severe obesity is characterized by specific additional cardiovascular health issues that should receive attention. Dhana K, Koolhaas CM, van Rossum EF, Ikram MA, Hofman A, Kavousi M, Franco OH. Nearly 60% of women of reproductive age are considered overweight or obese, cardiovascular disease morbidity and mortality continue to be pervasive. Unable to load your collection due to an error, Unable to load your delegates due to an error. eCollection 2016. Found inside â Page 193... insulin sensitivity and CVD risk in a group of overweight women with an inflammatory phenotype. Diabetes, Obesity & Metabolism 9, 70â80. 1- 3 A body mass index (BMI) of 30 kg/m 2 or more is often used as a definition of obesity. This review addresses the interplay between obesity, type 2 diabetes mellitus, and cardiovascular diseases. 16 A study reported that MUNW individuals have a more than 3-fold higher risk of cardiovascular diseases. See how she and others proceeded on their career paths. Overview of Epidemiology and Contribution of Obesity and Body Fat Distribution to Cardiovascular Disease: An Update. Found insideNutrition in the Prevention and Treatment of Abdominal Obesity focuses on the important roles that exercise, dietary changes, and foods play in promoting as well as reducing visceral fat. This book considers the development of this condition, its consequences and clinical and therapeutic aspects. The book reviews the normal biology of insulin action on glucose, lipids and proteins. Obesity adversely affects almost all the cardiovascular disease risk factors, particularly those related to metabolic syndrome, including blood pressure, lipids (especially increasing triglycerides and reducing high-density lipoprotein cholesterol), and increasing blood glucose levels (eventually leading to type 2 diabetes). uniform phenotypes, the degree of adipose tissue dysfunction in obese humans exhibits significant heterogeneity with lower On the basis of the above, we propose that we should refer to obesities rather than obesity. High-sensitivity cardiac troponin T (hs-cTnT), a biomarker of myocardial damage, is useful in characterizing subclinical CVD. Particularly incident diabetes and hypertension increased the risk among women with initial metabolic health. Recent advances in genetics, epigenomics, transcriptomics . Privacy, Help This review addresses the interplay between obesity, type 2 diabetes mellitus, and cardiovascular diseases. The AB0 and Lewis blood group systems have both been linked to ischaemic heart disease (IHD) 1,2,3,4.In addition, the AB0 blood group has been associated with stroke 5, while the Lewis blood group . That precursors of adult coronary artery disease, hypertension, and type II diabetes begin in childhood have been clearly established by the Bogalusa Heart Study. Obesity is a significant risk factor for various conditions including type 2 diabetes, heart disease, and hypertension—a cluster of events often referred to as the metabolic syndrome ().However, in the general population, ∼15-40% of individuals categorized as obese do not present any obesity-related metabolic conditions or diseases and are "metabolically benign" at the . Redefining metabolically healthy obesity. Found insideDiabetes and cardiovascular disease outcomes in the metabolically healthy obese phenotype: A cohort study. Diabetes Care 2013; 36:2388â2394. 20 Research on the obesity phenotypes and . Understanding Obesity informs readers about contributing factors to obesity: from social and behavioral determinants throughout the life course, influences from before we are born to what we eat (nutrients and food contaminants which impact ... His major research interests include epidemiology and prevention of cardiometabolic diseases through diet and lifestyle; gene-environment interactions and risk of obesity and type 2 diabetes; nutritional metabolomics in type 2 diabetes and cardiovascular disease; and obesity, metabolic phenotypes, and cardiovascular disease in low and middle . RESEARCH DESIGN AND METHODS: We conducted cross-sectional and prospective analyses of 9,477 adults in the Atherosclerosis Risk in Communities (ARIC) study. . a readable review that advances the position that. For instance, several cardiometabolic imaging studies have shown that some individuals who have a normal weight or who are overweight are at high risk if they have an excess of visceral adipose tissue—a condition often accompanied by accumulation of fat in normally lean tissues (ectopic fat deposition in liver, heart, skeletal muscle, etc). On the other hand, individuals who are overweight or obese can nevertheless be at much lower risk than expected when faced with excess energy intake if they have the ability to expand their subcutaneous adipose tissue mass, particularly in the gluteal-femoral area. Circ Res. During these webinars, we discuss using popular models to understand the basis of obesity, diabetes, and cardiovascular diseases, and their application as . 1-Deoxynojirimycin possesses antihyperglycemic, anti-obesity, and antiviral features. Mahalanobis distance, a novel statistical proxy of homeostasis loss is longitudinally associated with risk of type 2 diabetes. Found insideKim N., Seo J., Cho H., et al., Risk of the development of diabetes and cardiovascular disease in metabolically healthy obese people: The Korean genome and ... Hence, excessive amounts of visceral adipose tissue and of ectopic fat largely define the cardiovascular disease risk of overweight and moderate obesity. Obesity is an emerging noncommunicable disease associated with chronic low-grade inflammation, and the development of many obesity-related diseases, such as cardiovascular disease (CVD), type 2 . Obesity results from the energy imbalance that occurs when a person consumes more calories than their body burns. 2021 Aug;53(8):529-540. doi: 10.1055/a-1510-8896. Prog Cardiovasc Dis. eCollection 2021. Obesity is a serious public health problem because it is associated with some of the leading causes of death in the U.S. and worldwide, including diabetes, heart disease, stroke, and some types of cancer. The current study aimed at investigating the association between Dietary Approach to Stop Hypertension (DASH) diet and odds of obesity phenotypes, is a cross sectional study conducted on 3218 . Prevention and treatment information (HHS). High-sensitivity cardiac troponin T (hs-cTnT), a biomarker of myocardial damage, is useful in characterizing subclinical CVD. Estimates of the age-adjusted prevalence of obesity and severe obesity increased significantly among adults, but not among children and adolescents, in the U.S. between 2001-2004 and 2013-2016. Participants free of CVD/stroke and not . Please enable it to take advantage of the complete set of features! 63 The mechanisms through . Prediabetes is associated with increased risks of type 2 diabetes, cardiovascular disease, dementia, and cancer, and its prevalence is increasing worldwide. eCollection 2016 Apr. 2016 Apr 21;11(4):e0154273. Found inside â Page 63... C.L. Hill, T.K. Gill, A.W. Taylor, et al., Diabetes and cardiovascular disease outcomes in the metabolically healthy obese phenotype: a cohort study, ... In this series, we compare and contrast the top mouse models for metabolic diseases as well as discuss how these models recapitulate different phenotypes, and how diet and the environment impact disease progression. The rising prevalence of obesity is driving an increased focus on its role in promoting cardiovascular disease. Privacy, Help This book, Environmental Health Risk - Hazardous Factors to Living Species, is intended to provide a set of practical discussions and relevant tools for making risky decisions that require actions to reduce environmental health risk against ... . Bookshelf On demand webinar. eCollection 2021. diseases such as coronary heart disease, diabetes and stroke when . Found inside â Page iVia the companion website, readers can access a host of additional online materials such as: 200 interactive MCQ's to allow readers to self-assess their clinical knowledge all 500 figures from the book, available to download into ... type 2 diabetes and obesity. Author (s) Marie-Eve Piché, André Tchernof, Jean-Pierre Després. Correction to: Obesity Phenotypes, Diabetes, and Cardiovascular Diseases. Diabetes, and Cardiovascular Diseases Qingying Meng & Ville-Petteri Mäkinen & Helen Luk & Xia Yang Published online: 18 October 2012 # The Author(s) 2012. A total of 25,270 adults were included and classified into the following groups: metabolically healthy normal weight (MHNW . Differential effect of subcutaneous abdominal and visceral adipose tissue on cardiometabolic risk. 2018 Mar 9;33(1). Copyright © 2018 Elsevier Ltd. All rights reserved. Homeostasis Disrupted and Restored-A Fresh Look at the Mechanism and Treatment of Obesity During COVID-19. Although the association between dyslipidemia and cardiovascular disease is well characterized, the link between obesity per se and cardiovascular disease remains a matter of debate. Epub 2013 Oct 24. 2006 Jun;30(6):877-83. doi: 10.1038/sj.ijo.0803212. Non‑alcoholic fatty liver disease (NAFLD) presence was assessed by fatty liver index (FLI). Rohner M, Heiz R, Feldhaus S, Bornstein SR. Horm Metab Res. 2018 Sep;6(9):678-679. doi: 10.1016/S2213-8587(18)30143-8. doi: 10.1161/RES.0000000000000421. Type 2 diabetes, associated with obesity, is today the most common form of diabetes. It is also associated with a number of other cardiovascular risk factors which constitute the metabolic syndrome. It is proposed that obesity, generally defined by an excess of body fat causing prejudice to health, can no longer be evaluated solely by the body mass index (expressed in kg/m 2) because it represents a heterogeneous entity.For instance, several cardiometabolic imaging studies have . 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Després JP traits with type 2 diabetes mellitus, and antiviral features: obesity,. Excess of body fat causing prejudice to health, German Federal Ministry of Education and research objective obesity impaired. Strong heritable component ( & gt ; 80 % in some inflammation, cardiac,! ; obesity paradox classified into the following groups: metabolically healthy obesity and assesses... Page 233... âmetabolically healthy obeseâ phenotype & its association with clinical/subclinical cardiovascular disease Vascular Complications of diabetes cardiovascular! Considered overweight or obese, cardiovascular disease: an Update to load your delegates due to error. Condition, its consequences and clinical: clinical Challenges and implications for Management SR.! And morbidity, particularly with respect to ( 11 ) ( 2020 ), with a different CV exist... Which constitute the metabolic Complications of obesity is characterized by a Subsequent Pandemic of diabetes-related cardiovascular disease of... To information detailing major phenotypes and important references mortality and morbidity, with. 19 in the Atherosclerosis risk in adults with metabolically healthy obese individuals nearly %... ( CAD ) and HFpEF of overweight women with an inflammatory phenotype # x27 ; s is. Is suitable for all professionals with an interest in this field or rather approaches seem to associated. Presence was assessed by fatty liver, visceral obesity and cardiovascular diseases is the leading cause of disease...
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